Obliteration

Obliteration- Discard/Destruction deck used to empower Thanos or benefit Death. This is a deck which heavily relies on low-cost cards, however overall this deck can be easily edited to your playstyle. *Some recommended and optional cards in this build can be replaced with other similar cards if your collection does not contain those listed here.

Necessities:

Thanos- Can empower from 8 to 18 if all Infinity Stones have been placed once. Stones can also be used as canonfodder to prepare Death or as benched cards to fuel Devil Dinosaur.

Death- High power, cost can be easily reduced through destroying included lower-cost cards, can also be a great fallback if you can't manage to place all 6 Infinity Stones.

Carnage- Great reclaimer that wipes out your low-cost cards in nearly-filled locations, works brilliantly in unison with Bucky and Sabertooth. 

Deathlok- Medium-cost, medium power, great for reclaiming locations and providing an extra power buffer to ally cards, works great in unison with Bucky and Sabertooth.

Recommended:

Devil Dinosaur- Great backup incase you don't pull Thanos or Death, and can also work brilliantly if you can't maximise use of the Infinity Stones or your destruction cards in-play.

Bucky Barnes- High power, low-cost, great for controlling a location & works perfectly with destruction plays.

Killmonger- Can wipe out Infinity Stones, Deadpool, and Nova in an instant to change the tide of a match. He's also a great saboteur for destroying similar Thanos/Death deck strategies in opposition.

Nova- Low-cost to benefit Death, and helps to buff any remaining low power cards in the field, also benefits Killmonger.

Deadpool- If played right, can be a great power build-up use, also benefits Killmonger.

Wolverine- Works great in unison with Bucky, Sabretooth, Carnage, and Deathlok. Also works as a decent zone filler if all destroyer cards have been applied.

Sabretooth- Simple method; decent power, great re-application, relatively low-cost.

Optional:

Wasp- Good add on for card removal or hand-filling, generally no great benefits and no disadvantages.