The idea is to control locations, get Storm out early or Spider-man late, and limit/know where your opponent will go to just win the game with cards like Captain Marvel or Magneto, to focus your opponent on one zone and win the other two zones. Cards like the goblins will clog up your opponent's spaces as well, making it all the easier for you to predict where they will go.
Quake is an unknown, and juggernaut I think could be the first card replaced. I'm thinking Shang-Chi could be good if you always know where your opponent is going to play a card