Very simple deck:
* Play as many 2-power cards as humanly possible
* If you get Blue Marvel, play him turn 5
* If you get Cerebro, play him turn 6
* Play Mystique after Cerebro, possibly after Blue Marvel if you didn't get Cerebro
* Use your 2 cost cards to negatively affect the opponent where possible (Goose/Storm to lock a location, Ice Man to delay, etc)
* Use Brood and Mr Sinister to fully occupy all locations. Use Mr. Fantastic for a small boost on the other locations.
* Silver surfer is a worst case backup, no Cerebro or no Blue Marvel, you can try to play him, maybe there's better cards for this tho
It's insane how well Blue Marvel pairs with Cerebro. At max you can get BM, Cerebro, Mystique for +5 buff, meaning you will have 2 Locations with easy 28 power.