Get your cards buffed, destroy them and abuse the bounce back shenaniganz, Abomination comes over America Chavez because the 1 energy left might be used for a big T6 Deadpool play.
Deadpool -> Kill it, he'll be back bigger, play it again. Duh.
Nova -> You know what to do here.
Carnage -> Destroy your other cards, gets stronger, trigger the destroyed cards effects.
Bucky Barnes -> Carnage/Deathlok food and gives you a big token
Forge -> Deadpool/Sabretooth/Wolverine/ buff before their effect resolves.
Wolverine -> Good old bouncing Logan
Sabretooth -> Destroy it and put a 0-cost 4 power card card to your hand (Keeps any buffs)
Hulk Buster -> Deadpool/Sabretooth/Wolverine, buff before their effect resolves
Moon Girl -> Copy a 0-drop Sabretooth (Maybe buffed), a buffed Deadpool
Deathlock -> Deadpool/Nova/Bucky Barnes/Wolverine/Sabretooth to trigger the cards destroy effect.
Killmonger -> Deadpool, Nova and any 1-cost your opponent tries do use
Abomination -> Game finisher with 1 energy left that can be spent on a massive T6 Abomination + Deadpool play.