Starve your opponent of resources by denying draws, stealing/milling cards and emptying their hand. Win locations with hand size/buff synergies.
I am not sure about Doctor Octopus (38) and Spider-Man (116) , I'm pretty sure America Chavez (4) is the right 6 drop, since it makes your other draws more consistent and gives you a guaranteed 6 if you want it on turn 6. It's also possible I have slightly too much stuff to keep hand-size high, let me know if you have any ideas :)
