I've climbed with this deck from 10 to 50 this season ,and I don't even play that much ,mostly just to do dailies. The idea is to guarantee a win on one location with Spider-Man / Professor X combo ,or Storm / Jessica Jones or Storm / Warpath also works great ,and just win the other location with Destroyer .
Armor and Cosmo are ways to negate Destroyer On reveal.
Other cards are here just to add enough power to win a location ,since Destroyer is usually enough to win one on his own.
I've played a few version of this deck ,this one works best. Enjoy.
Edit: I've swapped out Lizard and Nova for Colossus and Iron Man ,wich seems better ,as Iron Man is unmatched power push and Colossus can add some power to Destroyer lane ,if 16 power is not enough. Hope you enjoy!