The key strategy is to gather Moon Girl and Nova in your hand. Its important to keep one field empty (at least 3 spaces) to pull the combo. Once you have copied an extra Nova, you need to wait for Deathlock.
There is some luck needed with your draws but that can be compensated with many 1s and Kazar. Wolfsbane is also a great card to throw when things aren't going to your likings.
I like to tempo with Wolverine and later drop 2 Novas and Deathlock. Try and fill as much of the field before doing the combo.
Enchantress is great for knocking out strong ongoing abilities. Like the Dino and Iron Man.