Most of the cards interact with destruction effects, but here are the reasons for including the ones that dont.
Mister Sinister - Fills a location faster for better Carnage payoffs
Scarlet Witch - Sometimes there's just a bad location that you need to fix, decent stats too.
Hulk Buster - A surprise heavy hitter. If you can graft it to Sabretooth that gets destroyed, you get an 8 power 0 drop that you can place where needed.
Hobgoblin - Tough to deal with for opponent.